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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Carbon monoxide-releasing molecules ： ウィキペディア英語版 Carbon monoxide-releasing molecules Carbon monoxide-releasing molecules (CO-RMs) are chemical compounds that release controlled amounts of carbon monoxide (CO) to cells and tissues and are being developed as potential therapeutic agents.〔Vicki L Mahan "Neuroprotective, neurotherapeutic, and neurometabolic effects of carbon monoxide" Medical Gas Research 2012, 2:32. .〕〔Motterlini R and Otterbein LE. "The therapeutic potential of carbon monoxide" Nat. Rev. Drug Discov. 9:728-743, 2010.〕 Although long recognized as a poison, CO also exhibits beneficial effects in small doses. These effects include anti-inflammatory activity, vasodilatation, and cardioprotection. CO is produced in mammals during the degradation of heme by heme oxygenase-1, a redox-sensitive enzyme induced by oxidative stress.〔Tenhunen R, Marver HS and Schmid R. "Microsomal heme oxygenase. Characterization of the enzyme" J Biol Chem. 244:6388-94, 1969.〕〔Maines MD, Trakshel GM, Kutty RK. "Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible" J. Biol. Chem. 261:411-9, 1986.〕 It is this enzymatic reaction that inspired the development of synthetic CO-RMs.〔Motterlini R, Sawle P, Hammad J, Bains SK, Alberto R, Foresti R and Green CJ. "CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule" FASEB J. 19:284-286, 2005.〕 Synthetic CO-RMs are typically metal carbonyl complexes. A representative CO-RM that has been extensively characterized both from a biochemical and pharmacological view point is the ruthenium(II) complex Ru(glycinate)Cl(CO)3, also known as CORM-3.〔Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R and Motterlini R. "Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule" Cir. Res. 93:e2-e8, 2003.〕 ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Carbon monoxide-releasing molecules」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.